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Soft Tissue Sarcomas Interactive Course - Case 2Author:André Mascarenhas Oliveira Pathology Resident - Mayo Clinic, Rochester, MN - USA Radiology Comments: Guilherme Baptista Villa Radiology Resident - Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil |
A 45-year-old man presented with 6-month history of a deep seated and painless soft-tissue mass. A magnetic resonance imaging was performed and showed a 10 cm mass with a signal intensity close to the muscle's sign on T1. The mass was completely excised and on the macroscopic examination, it was white, fleshy, well-circumscribed and measured approximately 10 cm in greatest dimension. The microscopic exam disclosed a fascicular proliferation of spindle-shaped cells with mild to moderate mitotic activity and few areas of necrosis (figures 1-4). Immunohistochemical studies revealed the following profile:
 (click image to zoom) Figure 1. Proliferation of spindle cells in a characteristic herringbone pattern (H&E, 160X). [Slides provided by AG Nascimento, MD. Mayo Clinic, Rochester, MN, USA] |
 (click image to zoom) Figure 2. Proliferation of spindle cells in a characteristic herringbone pattern (H&E, 160X). [Slides provided by AG Nascimento, MD. Mayo Clinic, Rochester, MN, USA] |
(click image to zoom) Figure 3. Increased mitotic activity in a high grade tumor (H&E, 400X). [Slides provided by AG Nascimento, MD. Mayo Clinic, Rochester, MN, USA] |
 (click image to zoom) Figure 4. Increased mitotic activity in a high grade tumor (H&E, 400X). [Slides provided by AG Nascimento, MD. Mayo Clinic, Rochester, MN, USA] |
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