Questions and Anwsers


Question



What are the diagnostic criteria for Neurofibromatosis?

Answer

There are two types of Neurofibromatosis. Type 1 and 2.

  • Neurofibromatosis type 1(NF 1) or Von Recklinghausen' s disease

    A patient meeting two or more of the following criteria can be diagnosed as suffering from NF 1

    1 - Neurofibromas - Two or more, or one plexiform neurofibroma
    2 - Café-au-lait macules - Six or more measuring 1,5 cm in their greatest dimension
    3 - Freckling - In the axillary or inguinal areas
    4 - Optic glioma
    5 - Iris hamartomas(Lisch nodules) - Two or more
    6 - Sphenoid dysplasia or thinning of the cortex of the long bones
    7 - First-degree relative

  • Neurofibromatosis type 2 (NF 2)

    NF 2 is characterized by bilateral acoustic neurofibromas and about 40% of patients have a few café-au-lait macules.

    For a detailed review on Neurofibromatosis go to Neurology/Neurofibromatosis

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